| VWF |
| LOCUS ID | 7450 | ||||||||||||||||
| GENE_SYMBOL | VWF | ||||||||||||||||
| GENE NAME | von Willebrand facto | ||||||||||||||||
| SYNONYMNS | VWD, F8VWF | ||||||||||||||||
| CHROMOSOME | 12 | ||||||||||||||||
| HOMOLOGENE ID | 466 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Recent studies have shown that increased plasma levels of Von Willebrand factor (VWF) and reduced plasma levels of enzyme ADAMTS13 are associated with diabetic nephropathy and an increased risk of developing cardiovascular disease, suggesting that these markers of hypercoagulability may contribute to an increased risk of cardiovascular disease in diabetic patients with impaired renal function. | 23159842 |
| Cardiovascular | 1. An elevated level of von Willebrand factor (VWF) in diabetic patients is associated with increased risk of thrombotic cardiovascular events. | 25814526 |
| Neuropathy | 1. Diabetics with neuropathy showed significantly elevated FVIII and vWF in comparison with diabetics without neuropathy and controls. | 8403679 |