WT1
LOCUS ID7490
GENE_SYMBOLWT1
GENE NAMEWilms tumor 1
SYNONYMNSGUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1
CHROMOSOME11
HOMOLOGENE ID11536
microRNAsNANA
GENE SUMMARY
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich D-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the materl and paterl alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes R editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The predomint presence of WT1 protein in Urinary exosomes of diabetic patients and increase in its expression level with decline in renal function suggest that it could be useful as early non-invasive marker for diabetic nephropathy.23544132