XBP1
LOCUS ID7494
GENE_SYMBOLXBP1
GENE NAMEX-box binding protei
SYNONYMNSXBP2, TREB5, XBP-1, TREB-5
CHROMOSOME22
HOMOLOGENE ID3722
microRNAsNANA
GENE SUMMARY
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the D binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endop

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Expression of the transcription factor XBP1 and the ER chaperones HSPA5 and HYOU1 were increased, but the proapoptotic gene DDIT3 was unchanged. These findings were replicated in an independent cohort of patients with established DN by real-time reverse transcriptase-PCR.18776125
Insulin resistance and inflammation1.knockdown of XBP1 by siRNA markedly mitigated the protective effects of preconditioning against inflammation.31630283