XIAP
LOCUS ID331
GENE_SYMBOLXIAP
GENE NAMEX-linked inhibitor of apoptosis
SYNONYMNSAPI3, ILP1, MIHA, XLP2, BIRC4, IAP-3, hIAP3, hIAP-3
CHROMOSOMEX
HOMOLOGENE ID901
microRNAsNANA
GENE SUMMARY
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by medione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alterte splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. XIAP gene delivery through the neurosurgical delivery of viral vectors may provide a means for neuroprotection in ALS and diabetic neuropathy.16823314