XRCC1
LOCUS ID7515
GENE_SYMBOLXRCC1
GENE NAMEX-ray repair complementing defective repair in Chinese hamster cells 1
SYNONYMNSRCC
CHROMOSOME19
HOMOLOGENE ID31368
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is involved in the efficient repair of D single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with D ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in D processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. Significant up-regulation of the MSH2 (2. 49-fold, P=0.001), XRCC1 (2. 11-fold, P=0.001) and ATM (2. 15-fold, P=0.003) genes was observed in patients with T2DM and CAD.26088318
Retinopathy1. The polymorphisms in the D repair genes PARP-1 and XRCC1 tended to associate significantly with DR. While Val762Ala polymorphism was associated with reduced susceptibility to DR, the Arg399Gln polymorphism contributed an elevated to risk for DR in South-Indian T2DM individuals.24621175