STEAP4
LOCUS ID79689
GENE_SYMBOLSTEAP4
GENE NAMESTEAP4 metalloreductase
SYNONYMNSTIARP, STAMP2, TNFAIP9
CHROMOSOME7
HOMOLOGENE ID36422
SOURCEMICE
PMIDs24467451
GENE SUMMARY
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using D(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Altertively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

OBSERVATION
1. STAMP2 is expressed in human and mouse macrophages, and regulates foam cell formation. STAMP2 is expressed in both human and mouse atherosclerotic plaques, and its deficiency promotes atherosclerosis in mice. STAMP2 overexpression could exert a protective effect on diabetic atherosclerosis by reducing IR and diminishing macrophage apoptosis.