ACE2
LOCUS ID59272
GENE_SYMBOLACE2
GENE NAMEangiotensin I converting enzyme 2
SYNONYMNSACEH
CHROMOSOMEX
HOMOLOGENE ID41448
SOURCEHUMAN
PMIDs15192839
GENE SUMMARY
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functiol receptor for the spike glycoprotein of the human coroviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

OBSERVATION
1. Comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).Allele D(RR=1.50) and genotype DD(RR=1.33) of ACE gene seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.