A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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ACE2 |
LOCUS ID | 59272 | |||||
GENE_SYMBOL | ACE2 | |||||
GENE NAME | angiotensin I converting enzyme 2 | |||||
SYNONYMNS | ACEH | |||||
CHROMOSOME | X | |||||
HOMOLOGENE ID | 41448 | |||||
SOURCE | HUMAN |
PMIDs | 15192839 |
GENE SUMMARY |
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The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functiol receptor for the spike glycoprotein of the human coroviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008] |
OBSERVATION |
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1. Comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).Allele D(RR=1.50) and genotype DD(RR=1.33) of ACE gene seemed to be a genetic risk factor for type 2 diabetes myocardial infarction. |