A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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AGER |
LOCUS ID | 177 | |||||
GENE_SYMBOL | AGER | |||||
GENE NAME | advanced glycosylation end product-specific receptor | |||||
SYNONYMNS | RAGE | |||||
CHROMOSOME | 6 | |||||
HOMOLOGENE ID | 883 | |||||
SOURCE | HUMAN |
PMIDs | 21521347 |
GENE SUMMARY |
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The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011] |
OBSERVATION |
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1. AGER 82S allele showed a protective effect on CAD severity in the presence of T2DM in Chinese Han population |