A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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APOC3 |
LOCUS ID | 345 | |||||
GENE_SYMBOL | APOC3 | |||||
GENE NAME | apolipoprotein C-III | |||||
SYNONYMNS | HALP2, APOCIII | |||||
CHROMOSOME | 11 | |||||
HOMOLOGENE ID | 81615 | |||||
SOURCE | HUMAN |
PMIDs | 25692924 |
GENE SUMMARY |
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Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008] |
OBSERVATION |
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1. In humans, plasma apoC-III levels are elevated during both hyperlipidemia and diabetes. The combination of these roles makes apoC-III an important therapeutic target for the management and prevention of CVD. |