A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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PON3 |
LOCUS ID | 5446 | |||||
GENE_SYMBOL | PON3 | |||||
GENE NAME | paraoxonase 3 | |||||
SYNONYMNS | ||||||
CHROMOSOME | 7 | |||||
HOMOLOGENE ID | 37371 | |||||
SOURCE | HUMAN |
PMIDs | 25964115 |
GENE SUMMARY |
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This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008] |
OBSERVATION |
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1. Elevated apoA-I glycation and decreased activities of HDL-associated PON1 and PON3, and their interaction are associated with the presence and severity of CAD in patients with T2DM. |