| SOD2 |
| LOCUS ID | 6648 | ||||
| GENE_SYMBOL | SOD2 | ||||
| GENE NAME | superoxide dismutase 2, mitochondrial | ||||
| SYNONYMNS | IPOB MNSOD MVCD6 | ||||
| CHROMOSOME | 6 | ||||
| HOMOLOGENE ID | 530 | ||||
| SOURCE | MICE |
| PMIDs | 24078136 |
| GENE SUMMARY |
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| This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| OBSERVATION |
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| 1. Aggravation of diabetic nephropathy in BCL-2 interacting cell death suppressor (BIS)-haploinsufficient mice together with impaired induction of superoxide dismutase (SOD) activity. However, levels of superoxide dismutase (SOD)1 and SOD2 increased on the induction of diabetes in BIS-WT mice but not in BIS-HT mice, correlating with the total SOD activity. An in vitro study showed that knockdown of BIS production also resulted in impaired induction of SOD activity as well as SOD levels in HK-2 and NMS cells, concomitant with significant ROS accumulation. CONCLUSION/INTERPRETATION: Our results suggest that the decreased antioxidant capacity of BIS aggravates diabetic nephropathy in diabetic BIS-HT mice, possibly as a result of the disruption in the regulation of SOD protein quality under oxidative stress. |