| ADCY5 |
| LOCUS ID | 111 | ||||||||||
| GENE_SYMBOL | ADCY5 | ||||||||||
| GENE NAME | adenylate cyclase 5 | ||||||||||
| SYNONYMNS | AC5, FDFM | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 11213 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Altertively spliced transcript var |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Thus, decreasing sympathetic signalling through loss of AC5 is not only a mechanism to improve exercise performance, but is also a mechanism to improve healthful aging, as exercise also protects against diabetes, obesity, and cardiovascular disease, which all limit healthful aging. | 26424149 |