| CF6 |
| LOCUS ID | 522 | ||||||||||
| GENE_SYMBOL | CF6 | ||||||||||
| GENE NAME | ATP synthase, H+ tra | ||||||||||
| SYNONYMNS | F6, CF6, ATP5, ATPM, ATP5A | ||||||||||
| CHROMOSOME | 21 | ||||||||||
| HOMOLOGENE ID | 1272 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. Th |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. High sodium, high glucose, and obesity are important risk factors for age-related diseases such as cardiovascular disease (CVDs), stroke, and cancer. Coupling factor 6 (CF6) is released from vascular endothelial cells and functions as a circulating peptide that inhibits prostacyclin and nitric oxide generation by intracellular acidosis. High glucose elevates CF6 by activation of protein kinase C and p38 mitogen-activated protein kinase, whereas CF6 causes type 2 diabetes mellitus, resulting in a high glucose vicious cycle. | 28359367 |