| COMT |
| LOCUS ID | 1312 | ||||||||||
| GENE_SYMBOL | COMT | ||||||||||
| GENE NAME | catechol-O-methyltra | ||||||||||
| SYNONYMNS | HEL-S-98n | ||||||||||
| CHROMOSOME | 22 | ||||||||||
| HOMOLOGENE ID | 30982 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found i |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. COMT rs4680 high-activity G-allele was associated with lower HbA1c and modest protection from type 2 diabetes. The directionality of COMT associations was concordant with those previously observed for cardiometabolic risk factors and CVD. | 27282867 |