| CYP4F3 |
| LOCUS ID | 4051 | ||||||||||
| GENE_SYMBOL | CYP4F3 | ||||||||||
| GENE NAME | cytochrome P450 fami | ||||||||||
| SYNONYMNS | CPF3 CYP4F LTB4H | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 4051 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member o |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. These alterations induced by Type II diabetes in the endogenous pathway (CYP450) of arachidonic acid metabolism may increase the risk for cardiovascular disease by disrupting the fine equilibrium between cardioprotective (CYP2J/CYP2C-generated) and cardiotoxic (CYP4A/CYP4F-generated) metabolites of arachidonic acid. | 29023376 |