| CYP7A1 |
| LOCUS ID | 1581 | ||||||||||
| GENE_SYMBOL | CYP7A1 | ||||||||||
| GENE NAME | cytochrome P450 fami | ||||||||||
| SYNONYMNS | CP7A, CYP7, CYPVII | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 30987 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygeses which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, wh |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. 7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from cholesterol to bile acids synthesis, is encoded by CYP7A1 gene. Its single nucleotide polymorphisms (SNPs) influence serum lipid levels and may be related to impaired lipid profile leading to coronary artery disease (CADThe CYP7A1 rs7833904 polymorphism may modify the risk of CAD. | 25944972 |