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FKBP4 |
LOCUS ID | 2288 | ||||||||||
GENE_SYMBOL | FKBP4 | ||||||||||
GENE NAME | FK506 binding protei | ||||||||||
SYNONYMNS | HBI, p52, Hsp56, FKBP51, FKBP52, FKBP59, PPIase | ||||||||||
CHROMOSOME | 12 | ||||||||||
HOMOLOGENE ID | 36085 |
microRNAs | NA | NA |
GENE SUMMARY |
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interact |
OBSERVATIONS |
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Complication | Evidence | PMID |
Cardiovascular | 1. Many individual genes within the PPIase family are associated with several age-related diseases including cardiovascular diseases (CVDs), atherosclerosis, type II diabetes (T2D), chronic kidney disease (CDK), neurodegeneration, cancer and age-related macular degeneration (AMD), in addition to the ageing process itself. | 25986561 |