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GCKR |
LOCUS ID | 2646 | ||||||||||
GENE_SYMBOL | GCKR | ||||||||||
GENE NAME | glucokinase (hexokin | ||||||||||
SYNONYMNS | GKRP, FGQTL5 | ||||||||||
CHROMOSOME | 2 | ||||||||||
HOMOLOGENE ID | 1139 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an ictive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Cardiovascular | 1. our data indicated that the favorable associations of higher vegetable and fish intakes on TG levels are dependent on the genetic background of an individual." [2] " In particular, at-risk TT- genotype carriers of the GCKR variant may derive more benefits from a high fish intake, while the CC-genotype carriers may find further benefits from a high consumption of vegetable. | 26234566 |