GLUL
LOCUS ID2752
GENE_SYMBOLGLUL
GENE NAMEglutamate-ammonia li
SYNONYMNSGS, GLNS, PIG43, PIG59
CHROMOSOME1
HOMOLOGENE ID37567
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell sigling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. These extend the association of GLUL rs10911021 to incident CVD morbidity and mortality in the setting of T2D.26395743