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ISL1 |
LOCUS ID | 3670 | ||||||||||
GENE_SYMBOL | ISL1 | ||||||||||
GENE NAME | ISL LIM homeobox 1 | ||||||||||
SYNONYMNS | Isl-1, ISLET1 | ||||||||||
CHROMOSOME | 5 | ||||||||||
HOMOLOGENE ID | 1661 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. |
OBSERVATIONS |
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Complication | Evidence | PMID |
Cardiovascular | 1. The key findings of our study demonstrate that miR-128-3p aggravates cardiovascular calcification and IR in T2DM rats by downregulating ISL1 through the activation of the Wnt pathway. | 30341898 |