| KLF5 |
| LOCUS ID | 688 | ||||||||||
| GENE_SYMBOL | KLF5 | ||||||||||
| GENE NAME | Kruppel like factor | ||||||||||
| SYNONYMNS | CKLF, IKLF, BTEB2 | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 37520 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and i |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. Reduced expression of endothelial nitric oxide synthase (eNOS) is a hallmark of endothelial dysfunction in diabetes, which predisposes diabetic patients to numerous cardiovascular complications including blunted angiogenesis. Hyperinsulinemia-induced KLF5 inhibited endothelial function and migration, and thereby compromised in vitro and in vivo angiogenesis. Collectively, the available data suggest that the augmentation of endothelial KLF5 expression by hyperinsulinemia may represent a novel mechanism for negatively regulating eNOS expression, and may thus help to explain for the T2DM-related endothelial dysfunction at the transcriptional level. | 31049798 |