| NPPA |
| LOCUS ID | 4878 | ||||||||||
| GENE_SYMBOL | NPPA | ||||||||||
| GENE NAME | Natriuretic peptide | ||||||||||
| SYNONYMNS | ANF, ANP, CDD, CDP, PND, ATFB6, ATRST2, CDD-ANF | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 4498 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the triuretic peptide family. triuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with triuretic-diuretic activity. Mutations in this gene have been associated with a |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Clinical studies have shown that although very high plasma NP level characterizes cardiac dysfunction and heart failure, a consistently reduced plasma NP level is observed in metabolic diseases such as obesity and type 2 diabetes. | 26037452 |