| PLIN1 |
| LOCUS ID | 5346 | ||||||||||
| GENE_SYMBOL | PLIN1 | ||||||||||
| GENE NAME | perilipin 1 | ||||||||||
| SYNONYMNS | PERI, PLIN, FPLD4 | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 2001 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Altertively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. PLIN1 and PLIN2 resulted significantly higher in CAD than in non-CAD subjects, as did apoptosis. | 26186298 |