| PLN |
| LOCUS ID | 5350 | ||||||||||
| GENE_SYMBOL | PLN | ||||||||||
| GENE NAME | phospholamban | ||||||||||
| SYNONYMNS | PLB | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 136758 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The e |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. These data suggest that PLN is O-Glccylated to induce the inhibition of its phosphorylation, which correlates to the deterioration of cardiac function. | 20484118 |