| SKP2 |
| LOCUS ID | 6502 | ||||||||||
| GENE_SYMBOL | SKP2 | ||||||||||
| GENE NAME | S-phase kinase assoc | ||||||||||
| SYNONYMNS | p45, FBL1, FLB1, FBXL1 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 55942 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modul |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. RESULTS: In patients with CVD, the circulating levels of IgG against native p45, MDA-modified p45, and MDA-modified p210 (IgGN-45, IgGMDA-45, and IgGMDA-210) were significantly lower than those in patients without CVD, whereas no difference was observed in anti-apo E autoantibody levels. | 30867375 |