| SOD3 |
| LOCUS ID | 6649 | ||||||||||
| GENE_SYMBOL | SOD3 | ||||||||||
| GENE NAME | superoxide dismutase | ||||||||||
| SYNONYMNS | EC-SOD | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 2334 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. CONCLUSION: Akt2 plays a critical role in ATP7A protein stabilization and translocation to plasma membrane in VSMCs, which contributes to full activation of vascular SOD3 that protects against endothelial dysfunction in T2DM | 29301787 |