| TACR1 |
| LOCUS ID | 6869 | ||||||||||
| GENE_SYMBOL | TACR1 | ||||||||||
| GENE NAME | tachykinin receptor | ||||||||||
| SYNONYMNS | SPR, NK1R, NKIR, TAC1R | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 20288 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. Gene expression of NPY2R, NPY5R, preproTachykinin A (SP gene), and NK1R and their respective protein expression were significantly reduced whereas that of NPY and NPY1R were unchanged in the right atrium of diabetic patients compared to nondiabetic patients.These results demonstrate that the expression of neuropeptides and their receptors in the diabetic heart is significantly impaired, and may be the link between neuropathy and cardiac complications | 22029806 |