| TPM1 |
| LOCUS ID | 7168 | ||||||||||
| GENE_SYMBOL | TPM1 | ||||||||||
| GENE NAME | tropomyosin 1 (alpha | ||||||||||
| SYNONYMNS | CMH3, TMSA,CMD1Y, LVNC9, C15orf13, HEL-S-265, HTM-alpha | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 121635 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyos |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. TPM1 and TPM4 genes encode proteins associated with cardiovascular and neoplastic disease.Expression of HMW isoforms from TPM1 is decreased in Type 2 diabetes. This is probably due to increased levels of inflammatory cytokines TNF alpha and IL-1beta in Type 2 diabetes. Lower levels of TPM1 mRNA reduce tumour suppression and could contribute to increased cancer risk in Type 2 diabetes. | 27649540 |