A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
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TLR9 |
LOCUS ID | 54106 | ||||
GENE_SYMBOL | TLR9 | ||||
GENE NAME | toll-like receptor 9 | ||||
SYNONYMNS | CD289 | ||||
CHROMOSOME | 3 | ||||
HOMOLOGENE ID | 68126 | ||||
SOURCE | MICE |
PMIDs | 24436372 |
GENE SUMMARY |
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] |
OBSERVATION |
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1. Genetic deletion of the innate immune receptor TLR9 exacerbated atherosclerosis in ApoE(-/-) mice fed a high-fat diet. CD4(+) T cells were identified as potential mediators of this effect. A type B CpG oligodeoxynucleotide TLR9 agonist reduced lesion severity, thus identifying a novel therapeutic approach in atherosclerosis |