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miRNAs

miRNA Gene Observation PMID
miR-33b2-DOGmiR-33b overexpression reduces insulin-induced 2-deoyxglucose (2-DOG) uptake in hepatic cells, suggesting that miR-33 plays a key role in regulating insulin signaling21946517
miR-33aABCA1Adenoviral miR-33a overexpression in human or mouse islets reduced ABCA1 expression, decreased glucose-stimulated insulin secretion, and increased cholesterol levels22315319
miR-128BAXmiR-128 has been shown to induce apoptosis in kidney cells through interaction with Bax21294859
miR-103/107CAV1Increased miR-103/107expression downregulates CAV121654750
miR-124FOXA2Upregulation 22156553
miR-192HNF1AUpregulation21294859
miR-194HNF1AmiR-194 is highly expressed in liver and in intestinal epithelial cells, where it is under regulation by Hnf1-aplha21294859
miR-24HNF1A, NEUROD1miR-24 overexpression downregulates HNF1A and NEUROD123761103
miR-802HNF1BOverexpression of miR-802 reduce HNF1B23389544
miR-29bINSIG1, CAV2Adenovirus-mediated overexpression of miR-29a/b/c in 3T3-L1 adipocytes could largely repress insulin-stimulated glucose uptake, presumably through inhibiting Akt activation.17652184
miR146IRAK1,TRAF6Increased expression18633110
miR-146aIRAK1,TRAF6,NFKBDecreased expression of miR-146a increased inflammatory gene expression22851573
miR375MTPNOverexpression of miR-375 suppress glucose induced insulin secretion15538371
miR-182NAUpregulation 22156553
miR-96NAUpregulation 22156553
miR-183NAUpregulation 22156553
miR-211NAUpregulation 22156553
miR-204NAUpregulation 22156553
miR-10bNADownregulation22156553
miR-10aNADownregulation22156553
miR-219-2-3pNADownregulation22156553
miR-144NADownregulation22156553
miR-338NADownregulation22156553
miR-199a-3pNADownregulation22156553
miR29aNAOverexpression17652184
miR-29cNAOverexpression17652184
miR-204NAUpregulation21294859
miR-672NAUpregulation21294859
miR-708NAUpregulation21294859
miR-25NOX4Decreased level of miR-25 increases NOX4 expression21071935
miR-143ORP8Overexpression of miR-143 downregulates ORP821441927
miR-451p38 MAPK signalling,The growth-inhibitory effect of miR-451 may be explained in part by miR-451-induced suppression of Ywhaz and p38 MAPK signalling,providing evidence for the potential role of miR-451 in early DN21827757
miR320PI3-Kthe p85 subunit of phosphatidylinositol 3-kinase (PI3-K) was found to be a potential target of miR-32019473196
miR-221ADIPOR1,ETS1Upregulation of miR221 downregulates ADIPOR1 and ETS123756832
miR-21PTENOur data demonstrate that miR-21 reverses high glucose and high insulin induced IR in 3T3-L1 adipocytes, possibly through modulating the PTEN-AKT pathway, and miR-21 may be a new therapeutic target for metabolic diseases such as T2DM and obesity.22956257
mir-181aSIRT1Overexpression of miR-181a downregulates SIRT122476949
miR-34aSIRT1Elevated levels of miR-34a reduces NAD(+) and Sirt1 by targeting NAMPT23834033
mir-9SIRT1High miR-9 expression reduce SIRT1 protein levels21288303
miR-141SLC25A3Overexpression of miR-141 decrease miR protein content23034391
miR-122SLC7A1miR-122 binding to 3UTR depresses SLC7A1 level19067360
miR-21SMAD7Overexpression of miR-21 enhanced high glucose induced inflammatory marhers23292313
miR-29cSPRY1Overexpression of miR-29c promotes Rho kinase activation21310958
miR34aVAMP2miR34a rise is linked to activation of p53 and results in sensitization to apoptosis and impaired nutrient-induced secretion18633110
miR-200bVEGFVEGF (target of miR-200b) mRNA and protein were elevated21357793
miR7aSNCA,CSPAmiR-7a levels are decreased in obese/diabetic mouse models and human islets from obese and moderately diabetic individuals with compensated beta cell function24789908
miR-200aNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR342-3pNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR335-5pNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR335-3pNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR-149PARP2Skeletal muscles from high fat diet (HFD)-fed obese mice exhibit low levels of miR-149 and high levels of PARP-2, and they show reduced mitochondrial function and biogenesis due to a decreased activation of the SIRT-1/PGC-1A pathway, suggesting that mitochondrial dysfunction in the skeletal muscle o24757201
miR-130aRUNX3Downregulated miR-130a in patients with Type 2 diabetes mellitus (DM) results in endothelial progenitor cells (EPC) dysfunction, including increased apoptosis, likely via its target runt-related transcription factor 3 (Runx3)24750349
miR29FOXA2miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis24722248
miR-195SIRT1These studies identified a novel mechanism whereby miR-195 regulates SIRT1-mediated tissue damage in diabetic retinopathy.24570140
miR-144IRS1Increased expression of miR-144 has been found to directly downregulate insulin receptor substrate 1 (IRS1), which is involved in insulin signaling at both the mRNA and protein level.Higher expression of miR-144 was significantly associated with T2D in Swedes (OR=2.43, p=0.035)24497980
miR126NAWe have shown that miR-126 is significantly reduced in plasma samples of T2DM susceptible individuals and T2DM patients24455723
miR1276CASP9,BMP2The expression of miR-125b-1 regulated by NF-KB has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-KB in TNFA-stimulated HeLa and HepG2 cells24418602
miR-1ET-125mM glucose decreased miR-1 expression and increased ET-1 mRNA and protein levels.These results indicate a novel glucose-induced mechanism of tissue damage, in which miR-1 regulates ET-1 expressions in diabetes. Identifying such mechanisms may lead to RNA based treatment for diabetic complications.24394957
miR-143ORP8This inhibition of insulin signaling by conditioned media (CM) and miR-143 is associated with a reduction in the expression of the oxysterol-binding protein-related protein 8 (ORP8).24333576
miR-187HIPK3The gene encoding homeodomain-interacting protein kinase-3 (HIPK3), a known regulator of insulin secretion, was identified as a direct target of miR-187 and displayed reduced expression in islets from individuals with type 2 diabetes.24149837
miR-184SLC25A22miR-184 inhibits insulin secretion in the MIN6 pancreatic beta-cell line through the repression of its target Slc25a22, a mitochondrial glutamate carrier.24109547
miR-25PTBP1Despite the increase in PTBP1 protein in the pancreas of diabetic rats, we observed insulin expression to be reduced alongside upregulation of miR-25 and miR-92a, suggesting an intricate regulation of insulin (bio)synthesis at its mRNA level24084692
miR-92aPTBP1Despite the increase in PTBP1 protein in the pancreas of diabetic rats, we observed insulin expression to be reduced alongside upregulation of miR-25 and miR-92a, suggesting an intricate regulation of insulin (bio)synthesis at its mRNA level24084692
miR-106aHIF1A,VEGFOver-expression of a common miRNA (miR-106a) significantly reduced the expression of HIF1A and VEGF and prevented high glucose-induced increased permeability.24018047
miR-155NR1H3miR-155 was upregulated in livers of obese mice, and that this increased expression was primarily detected in CD11b+ macrophage cells.23991091
miR-106bUCP1Ectopic expression of miR-106b and miR-93 suppressed the mRNA level of Ucp1, a selective hallmark of brown adipocytes. Furthermore, the expression levels of miR-106b and miR-93 are higher in brown adipose tissues of high fat diet-induced obese mice compared to control mice23954633
miR-125b-1NFKBThe expression of miR-125b-1 regulated by NF-KB has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-KB in TNFA-stimulated HeLa and HepG2 cells.24418602
miR-93UCP1Ectopic expression of miR-106b and miR-93 suppressed the mRNA level of Ucp1, a selective hallmark of brown adipocytes. Furthermore, the expression levels of miR-106b and miR-93 are higher in brown adipose tissues of high fat diet-induced obese mice compared to control mice23954633
miR-27aNAOverexpression of miR-106b, miR-27a and miR-30d in L6 cells decreased glucose consumption and glucose uptake, and reduced the expression of GLUT4, MAPK 14 and PI3K regulatory subunit beta.27165190
miR-100NAAdditionally, our in-vitro findings, and the miR-100 expression patterns in site-specific adipose tissue suggest miR-100 to modulate IGFR, mTOR and mediate adipogenesis.26973292
miR-103bSFRP4CONCLUSIONS: The results suggest that platelet-derived miR-103b could negatively regulate the expression of SFRP4 mRNA/protein in pre-DM2, indicating that miR-103b could be a novel biomarker for the early diagnosis of DM2.25820527
miR-106bSLC2A4Overexpression of miR-106b, miR-27a and miR-30d in L6 cells decreased glucose consumption and glucose uptake, and reduced the expression of GLUT4, MAPK 14 and PI3K regulatory subunit beta.27165190
miR-10aCREB1,HDAC3Contrarily, HDAC3 overexpression mediated by lentivirus decreased miR-10a content, and enhanced ACR value, CREB1 and FN formation in naive mice.Knockdown of HDAC3 with siRNA significantly caused the increase of miR-10a, resulting in the decrease in CREB1 and FN expression in kidney of HFD/STZ mice.27292126
miR-122NATaken together, our results provide new evidence that miR-122-regulated HCBP6 functions as a sensor protein to maintain intrahepatocyte TG levels.25855506
MiR-124aNAMiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.26897751
miR-130bNAOur findings suggest that serum miR-130b may be a new biomarker for the early diagnosis of DN in T2DM. Circulating miR-130b may possibly be involved in the pathological mechanism of DN, such as lipid metabolic disorders, oxidative stress, extracellular matrix deposition and renal fibrosis.25952368
miR-152PTENFinally, phosphatase and tensin homolog (PTEN) was identified as a direct target of miR-152 to mediate hepatic glycogen synthesis.26996529
miR-15bINSRFurthermore, the overexpression of miR-15b suppressed the protein expression of INSR through targeting INSR 3' untranslated region directly, resulting in an impairment of the insulin signaling and glycogen synthesis in hepatocytes.26179126
miR-16MEF2A,SLC2A4Further, ectopic expression of miR-16 enhanced insulin stimulated glucose uptake in skeletal myoblasts via the up-regulation of GLUT4 and MEF2A, two key players involved in insulin stimulated glucose uptake.26453808
miR-17TXNIPIn contrast, IFN-gamma increased pro-apoptotic TXNIP post-transcriptionally via induction of endoplasmic reticulum stress, activation of inositol-requiring enzyme 1 alpha (IRE-alpha), and suppression of miR-17, a microRNA that targets and down-regulates TXNIP. In fact, miR-17 knockdown was able to m26858253
miR-192ALDH3A2SCD and ALDH3A2 were demonstrated to be direct targets of miR-192*. To conclude, the present data identify miR-192* as a novel controller of adipocyte differentiation and lipid homeostasis.26747651
miR-192ALBCONCLUSIONS: These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.26881255
miR-194AKT1When miR-194 was down-regulated in vitro, western blot analysis showed an increased phosphorylation of AKT and GSK3beta in response to insulin, and an increase in expression of proteins controlling mitochondrial oxidative phosphorylation.27163678
miR-199b-5pKLThe increased serum klotho, mediated by miR-199b-5p, is a possible mechanism by which atrasentan prevents renal tubular injury in DN.26813039
miR-203SOCS3H.pylori infection could upregulate SOCS3, a well-known insulin signaling inhibitor, by downregulating miR-203.25689935
miR-206NAChow- and HFD-fed miR-206 KO mice have improved glucose tolerance and GSIS but unaltered insulin sensitivity.27221121
miR-22-3pNAFurthermore, in vivo silencing of miR-22-3p by antagomiR administration lowered random as well as fasting glucose levels in diabetic mice. miR-22-3p antagonism improved glucose tolerance and insulin sensitivity.26193896
miR-26aID1Diabetic dermal wounds treated with LNA-anti-miR-26a had increased expression of ID1, a downstream modulator or SMAD1, and decreased expression of the cell cycle inhibitor p27.26776318
miR-27aSLC2A4CONCLUSION: Our data suggested that miR-106b, miR-27a and miR-30d play crucial roles in the regulation of glucose metabolism by targeting the GLUT4 signalling pathway in L6 cells.27165190
miR-30dSLC2A4CONCLUSION: Our data suggested that miR-106b, miR-27a and miR-30d play crucial roles in the regulation of glucose metabolism by targeting the GLUT4 signalling pathway in L6 cells.27165190
miR-30dNAMiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.26897751
miR-320cTHBS1Deregulated miR-320c, which might have an impact on the TGF-beta-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies.26930277
miR-328BAATAnalyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation.26900752
miR-34a-5pEIF2AK3Conversely, silencing PERK alleviated stearic-acid-induced p53, miR-34a-5p and lipotoxicity.26969487
miR-4284NAInterestingly, we revealed a time and stage specific expression manner, as shown that expression of miR-4284 increased at the stage I of ASO and maintained the tendency to stage IV, while miR-4463 expression decreased at every stage of ASO; however, the expression of miR-4463 showed opposite changes26370316
miR-199a-3pLEPFFA, TNF-alpha, IL-6 and leptin significantly induced miR-199a-3p expression in mature human adipocytes, while resistin had the opposite effect. miR-199a-3p may represent a factor in the modulation of obesity-associated IR and inflammatory responses.27279151
miRNA-29FTO,STAT3,DNMT1Via DNMT suppression, milk exosomal miRNA-29s may reduce the magnitude of FTO methylation, thereby epigenetically increasing FTO expression in the milk consumer.Notably, the galactopoietic hormone prolactin upregulates the transcription factor STAT3, which induces miRNA-29 expression.26691922
miRNA-9-3pSIRT1Therefore, these findings demonstrated that the inhibition of miRNA-9-3p reduced the proliferation of HepG2 cells and lipid accumulation by upregulating the expression of SIRT1, indicating its potential as a therapeutic target.26459099
miRNA33b/16INSPlasma miRNA33b/16 levels revealed a positive correlation with plasma insulin level (r=0.326, P=0.021), serum C-peptide (r=0.280, P=0.049), and triglyceride (r=0.351, P=0.012), but no association with HDL-C (r=-0.210, P=0.143).27301461
miR-51GKThrough adenovirus mediated gain- and loss- of function study, we find that miR-451 negatively regulates hepatic gluconeogenesis and blood glucose levels in normal mice, and identify glycerol kinase (Gyk) as a direct target of miR-51.27495223
miR-15bCCND1The up-regulated miR-15b inhibited pancreatic beta-cell proliferation via targeting cyclin D1 and cyclin D2. Inhibition of miR-15b in LP islet cells restored beta-cell proliferation and insulin secretion. 27754789
miRNA-463-3pABCG4Interestingly, in type 2 diabetes human pancreatic islets, expression of miRNA-463-3p and insulin was upregulated and ABCG4 downregulated compared with nondiabetic controls, and their expression levels were closely correlated.27664094
miR-126NACirculating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.27321479
miR-346NATNF-alpha suppression of VDR in PBMCs and HK2 cells is mediated by miR-346.27552538