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miRNAs

miRNA Gene Observation PMID
miRNAGeneObservationPMID
miR-33b2-DOGmiR-33b overexpression reduces insulin-induced 2-deoyxglucose (2-DOG) uptake in hepatic cells, suggesting that miR-33 plays a key role in regulating insulin signaling21946517
miR-33aABCA1Adenoviral miR-33a overexpression in human or mouse islets reduced ABCA1 expression, decreased glucose-stimulated insulin secretion, and increased cholesterol levels22315319
miR-128BAXmiR-128 has been shown to induce apoptosis in kidney cells through interaction with Bax21294859
miR-103/107CAV1Increased miR-103/107expression downregulates CAV121654750
miR-124FOXA2Upregulation22156553
miR-192HNF1AUpregulation21294859
miR-194HNF1AmiR-194 is highly expressed in liver and in intestinal epithelial cells, where it is under regulation by Hnf1-aplha21294859
miR-24HNF1A, NEUROD1miR-24 overexpression downregulates HNF1A and NEUROD123761103
miR-802HNF1BOverexpression of miR-802 reduce HNF1B23389544
miR-29bINSIG1, CAV2Adenovirus-mediated overexpression of miR-29a/b/c in 3T3-L1 adipocytes could largely repress insulin-stimulated glucose uptake, presumably through inhibiting Akt activation.17652184
miR146IRAK1,TRAF6Increased expression18633110
miR-146aIRAK1,TRAF6,NFKBDecreased expression of miR-146a increased inflammatory gene expression22851573
miR375MTPNOverexpression of miR-375 suppress glucose induced insulin secretion15538371
miR-182NAUpregulation22156553
miR-96NAUpregulation22156553
miR-183NAUpregulation22156553
miR-211NAUpregulation22156553
miR-204NAUpregulation22156553
miR-10bNADownregulation22156553
miR-10aNADownregulation22156553
miR-219-2-3pNADownregulation22156553
miR-144NADownregulation22156553
miR-338NADownregulation22156553
miR-199a-3pNADownregulation22156553
miR29aNAOverexpression17652184
miR-29cNAOverexpression17652184
miR-204NAUpregulation21294859
miR-672NAUpregulation21294859
miR-708NAUpregulation21294859
miR-25NOX4Decreased level of miR-25 increases NOX4 expression21071935
miR-143ORP8Overexpression of miR-143 downregulates ORP821441927
miR-451p38 MAPK signalling,The growth-inhibitory effect of miR-451 may be explained in part by miR-451-induced suppression of Ywhaz and p38 MAPK signalling,providing evidence for the potential role of miR-451 in early DN21827757
miR320PI3-Kthe p85 subunit of phosphatidylinositol 3-kinase (PI3-K) was found to be a potential target of miR-32019473196
miR-221ADIPOR1,ETS1Upregulation of miR221 downregulates ADIPOR1 and ETS123756832
miR-21PTENOur data demonstrate that miR-21 reverses high glucose and high insulin induced IR in 3T3-L1 adipocytes, possibly through modulating the PTEN-AKT pathway, and miR-21 may be a new therapeutic target for metabolic diseases such as T2DM and obesity.22956257
mir-181aSIRT1Overexpression of miR-181a downregulates SIRT122476949
miR-34aSIRT1Elevated levels of miR-34a reduces NAD(+) and Sirt1 by targeting NAMPT23834033
mir-9SIRT1High miR-9 expression reduce SIRT1 protein levels21288303
miR-141SLC25A3Overexpression of miR-141 decrease miR protein content23034391
miR-122SLC7A1miR-122 binding to 3UTR depresses SLC7A1 level19067360
miR-21SMAD7Overexpression of miR-21 enhanced high glucose induced inflammatory marhers23292313
miR-29cSPRY1Overexpression of miR-29c promotes Rho kinase activation21310958
miR34aVAMP2miR34a rise is linked to activation of p53 and results in sensitization to apoptosis and impaired nutrient-induced secretion18633110
miR-200bVEGFVEGF (target of miR-200b) mRNA and protein were elevated21357793
miR7aSNCA,CSPAmiR-7a levels are decreased in obese/diabetic mouse models and human islets from obese and moderately diabetic individuals with compensated beta cell function24789908
miR-200aNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR342-3pNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR335-5pNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR335-3pNAAdipose tissue-specific down-regulation of miR-200a and miR-200b and the up-regulation of miR-342-3p, miR-335-5p, and miR-335-3p were observed24758184
miR-149PARP2Skeletal muscles from high fat diet (HFD)-fed obese mice exhibit low levels of miR-149 and high levels of PARP-2, and they show reduced mitochondrial function and biogenesis due to a decreased activation of the SIRT-1/PGC-1A pathway, suggesting that mitochondrial dysfunction in the skeletal muscle o24757201
miR-130aRUNX3Downregulated miR-130a in patients with Type 2 diabetes mellitus (DM) results in endothelial progenitor cells (EPC) dysfunction, including increased apoptosis, likely via its target runt-related transcription factor 3 (Runx3)24750349
miR29FOXA2miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis24722248
miR-195SIRT1These studies identified a novel mechanism whereby miR-195 regulates SIRT1-mediated tissue damage in diabetic retinopathy.24570140
miR-144IRS1Increased expression of miR-144 has been found to directly downregulate insulin receptor substrate 1 (IRS1), which is involved in insulin signaling at both the mRNA and protein level.Higher expression of miR-144 was significantly associated with T2D in Swedes (OR=2.43, p=0.035)24497980
miR126NAWe have shown that miR-126 is significantly reduced in plasma samples of T2DM susceptible individuals and T2DM patients24455723
miR1276CASP9,BMP2The expression of miR-125b-1 regulated by NF-KB has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-KB in TNFA-stimulated HeLa and HepG2 cells24418602
miR-1ET-125mM glucose decreased miR-1 expression and increased ET-1 mRNA and protein levels.These results indicate a novel glucose-induced mechanism of tissue damage, in which miR-1 regulates ET-1 expressions in diabetes. Identifying such mechanisms may lead to RNA based treatment for diabetic complications.24394957
miR-143ORP8This inhibition of insulin signaling by conditioned media (CM) and miR-143 is associated with a reduction in the expression of the oxysterol-binding protein-related protein 8 (ORP8).24333576
miR-187HIPK3The gene encoding homeodomain-interacting protein kinase-3 (HIPK3), a known regulator of insulin secretion, was identified as a direct target of miR-187 and displayed reduced expression in islets from individuals with type 2 diabetes.24149837
miR-184SLC25A22miR-184 inhibits insulin secretion in the MIN6 pancreatic beta-cell line through the repression of its target Slc25a22, a mitochondrial glutamate carrier.24109547
miR-25PTBP1Despite the increase in PTBP1 protein in the pancreas of diabetic rats, we observed insulin expression to be reduced alongside upregulation of miR-25 and miR-92a, suggesting an intricate regulation of insulin (bio)synthesis at its mRNA level24084692
miR-92aPTBP1Despite the increase in PTBP1 protein in the pancreas of diabetic rats, we observed insulin expression to be reduced alongside upregulation of miR-25 and miR-92a, suggesting an intricate regulation of insulin (bio)synthesis at its mRNA level24084692
miR-106aHIF1A,VEGFOver-expression of a common miRNA (miR-106a) significantly reduced the expression of HIF1A and VEGF and prevented high glucose-induced increased permeability.24018047
miR-155NR1H3miR-155 was upregulated in livers of obese mice, and that this increased expression was primarily detected in CD11b+ macrophage cells.23991091
miR-106bUCP1Ectopic expression of miR-106b and miR-93 suppressed the mRNA level of Ucp1, a selective hallmark of brown adipocytes. Furthermore, the expression levels of miR-106b and miR-93 are higher in brown adipose tissues of high fat diet-induced obese mice compared to control mice23954633
miR-125b-1NFKBThe expression of miR-125b-1 regulated by NF-KB has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-KB in TNFA-stimulated HeLa and HepG2 cells.24418602
miR-93UCP1Ectopic expression of miR-106b and miR-93 suppressed the mRNA level of Ucp1, a selective hallmark of brown adipocytes. Furthermore, the expression levels of miR-106b and miR-93 are higher in brown adipose tissues of high fat diet-induced obese mice compared to control mice23954633
miR-27aNAOverexpression of miR-106b, miR-27a and miR-30d in L6 cells decreased glucose consumption and glucose uptake, and reduced the expression of GLUT4, MAPK 14 and PI3K regulatory subunit beta.27165190
miR-100NAAdditionally, our in-vitro findings, and the miR-100 expression patterns in site-specific adipose tissue suggest miR-100 to modulate IGFR, mTOR and mediate adipogenesis.26973292
miR-103bSFRP4CONCLUSIONS: The results suggest that platelet-derived miR-103b could negatively regulate the expression of SFRP4 mRNA/protein in pre-DM2, indicating that miR-103b could be a novel biomarker for the early diagnosis of DM2.25820527
miR-106bSLC2A4Overexpression of miR-106b, miR-27a and miR-30d in L6 cells decreased glucose consumption and glucose uptake, and reduced the expression of GLUT4, MAPK 14 and PI3K regulatory subunit beta.27165190
miR-10aCREB1,HDAC3Contrarily, HDAC3 overexpression mediated by lentivirus decreased miR-10a content, and enhanced ACR value, CREB1 and FN formation in naive mice.Knockdown of HDAC3 with siRNA significantly caused the increase of miR-10a, resulting in the decrease in CREB1 and FN expression in kidney of HFD/STZ mice.27292126
miR-122NATaken together, our results provide new evidence that miR-122-regulated HCBP6 functions as a sensor protein to maintain intrahepatocyte TG levels.25855506
MiR-124aNAMiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.26897751
miR-130bNAOur findings suggest that serum miR-130b may be a new biomarker for the early diagnosis of DN in T2DM. Circulating miR-130b may possibly be involved in the pathological mechanism of DN, such as lipid metabolic disorders, oxidative stress, extracellular matrix deposition and renal fibrosis.25952368
miR-152PTENFinally, phosphatase and tensin homolog (PTEN) was identified as a direct target of miR-152 to mediate hepatic glycogen synthesis.26996529
miR-15bINSRFurthermore, the overexpression of miR-15b suppressed the protein expression of INSR through targeting INSR 3' untranslated region directly, resulting in an impairment of the insulin signaling and glycogen synthesis in hepatocytes.26179126
miR-16MEF2A,SLC2A4Further, ectopic expression of miR-16 enhanced insulin stimulated glucose uptake in skeletal myoblasts via the up-regulation of GLUT4 and MEF2A, two key players involved in insulin stimulated glucose uptake.26453808
miR-17TXNIPIn contrast, IFN-gamma increased pro-apoptotic TXNIP post-transcriptionally via induction of endoplasmic reticulum stress, activation of inositol-requiring enzyme 1 alpha (IRE-alpha), and suppression of miR-17, a microRNA that targets and down-regulates TXNIP. In fact, miR-17 knockdown was able to m26858253
miR-192ALDH3A2SCD and ALDH3A2 were demonstrated to be direct targets of miR-192*. To conclude, the present data identify miR-192* as a novel controller of adipocyte differentiation and lipid homeostasis.26747651
miR-192ALBCONCLUSIONS: These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.26881255
miR-194AKT1When miR-194 was down-regulated in vitro, western blot analysis showed an increased phosphorylation of AKT and GSK3beta in response to insulin, and an increase in expression of proteins controlling mitochondrial oxidative phosphorylation.27163678
miR-199b-5pKLThe increased serum klotho, mediated by miR-199b-5p, is a possible mechanism by which atrasentan prevents renal tubular injury in DN.26813039
miR-203SOCS3H.pylori infection could upregulate SOCS3, a well-known insulin signaling inhibitor, by downregulating miR-203.25689935
miR-206NAChow- and HFD-fed miR-206 KO mice have improved glucose tolerance and GSIS but unaltered insulin sensitivity.27221121
miR-22-3pNAFurthermore, in vivo silencing of miR-22-3p by antagomiR administration lowered random as well as fasting glucose levels in diabetic mice. miR-22-3p antagonism improved glucose tolerance and insulin sensitivity.26193896
miR-26aID1Diabetic dermal wounds treated with LNA-anti-miR-26a had increased expression of ID1, a downstream modulator or SMAD1, and decreased expression of the cell cycle inhibitor p27.26776318
miR-27aSLC2A4CONCLUSION: Our data suggested that miR-106b, miR-27a and miR-30d play crucial roles in the regulation of glucose metabolism by targeting the GLUT4 signalling pathway in L6 cells.27165190
miR-30dSLC2A4CONCLUSION: Our data suggested that miR-106b, miR-27a and miR-30d play crucial roles in the regulation of glucose metabolism by targeting the GLUT4 signalling pathway in L6 cells.27165190
miR-30dNAMiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.26897751
miR-320cTHBS1Deregulated miR-320c, which might have an impact on the TGF-beta-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies.26930277
miR-328BAATAnalyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation.26900752
miR-34a-5pEIF2AK3Conversely, silencing PERK alleviated stearic-acid-induced p53, miR-34a-5p and lipotoxicity.26969487
miR-4284NAInterestingly, we revealed a time and stage specific expression manner, as shown that expression of miR-4284 increased at the stage I of ASO and maintained the tendency to stage IV, while miR-4463 expression decreased at every stage of ASO; however, the expression of miR-4463 showed opposite changes26370316
miR-199a-3pLEPFFA, TNF-alpha, IL-6 and leptin significantly induced miR-199a-3p expression in mature human adipocytes, while resistin had the opposite effect. miR-199a-3p may represent a factor in the modulation of obesity-associated IR and inflammatory responses.27279151
miRNA-29FTO,STAT3,DNMT1Via DNMT suppression, milk exosomal miRNA-29s may reduce the magnitude of FTO methylation, thereby epigenetically increasing FTO expression in the milk consumer.Notably, the galactopoietic hormone prolactin upregulates the transcription factor STAT3, which induces miRNA-29 expression.26691922
miRNA-9-3pSIRT1Therefore, these findings demonstrated that the inhibition of miRNA-9-3p reduced the proliferation of HepG2 cells and lipid accumulation by upregulating the expression of SIRT1, indicating its potential as a therapeutic target.26459099
miRNA33b/16INSPlasma miRNA33b/16 levels revealed a positive correlation with plasma insulin level (r=0.326, P=0.021), serum C-peptide (r=0.280, P=0.049), and triglyceride (r=0.351, P=0.012), but no association with HDL-C (r=-0.210, P=0.143).27301461
miR-51GKThrough adenovirus mediated gain- and loss- of function study, we find that miR-451 negatively regulates hepatic gluconeogenesis and blood glucose levels in normal mice, and identify glycerol kinase (Gyk) as a direct target of miR-51.27495223
miR-15bCCND1The up-regulated miR-15b inhibited pancreatic beta-cell proliferation via targeting cyclin D1 and cyclin D2. Inhibition of miR-15b in LP islet cells restored beta-cell proliferation and insulin secretion.27754789
miRNA-463-3pABCG4Interestingly, in type 2 diabetes human pancreatic islets, expression of miRNA-463-3p and insulin was upregulated and ABCG4 downregulated compared with nondiabetic controls, and their expression levels were closely correlated.27664094
miR-126NACirculating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.27321479
miR-346NATNF-alpha suppression of VDR in PBMCs and HK2 cells is mediated by miR-346.27552538
hsa-mir-150 NA1: Deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM( 30598522). 2: Patie 30598522, 3
hsa-mir-15a NA1:Deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM( 30598522). 2:Patient 30598522, 3
hsa-miR-30a-5p NA1:Deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM( 30598522). 2:Patient
hsa-mir-196a-2 NAStudy was to evaluate the association of miRNA-146a G/C (rs2910164), and miRNA-196a2 C/T (rs11614913) polymorphisms with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent. The T allele of the miRNA-196a2 C/T (rs11614913) polymorphism is associated with t30560371
hsa-miR-30b-5p,TGFBRAP1,TGFBR2The expression of has-miR-30b-5p and has-miR-93-5p was linearly increased across TT, TC, and CC genotypes of rs2241797 in NGT, Ptrend values were 0.024 and 0.016, respectively.Our findings suggest that genetic polymorphisms of TGFBRAP1 may contribute to the genetic susceptibility of T2DM by mediatin30461200
hsa-miR-93-5pTGFBRAP1,TGFBR3The expression of has-miR-30b-5p and has-miR-93-5p was linearly increased across TT, TC, and CC genotypes of rs2241797 in NGT, Ptrend values were 0.024 and 0.016, respectively.Our findings suggest that genetic polymorphisms of TGFBRAP1 may contribute to the genetic susceptibility of T2DM by mediatin30461200
hsa-mir-423-3p,BMI and HbA1cThe post-training levels of miR-423-3p, miR-451a and miR-766-3p were significantly up-regulated, irrespective of exercise type (P<0.0026; 0.05/19), and targeted upstream pathways relevant to fatty acids biosynthesis and metabolic regulation. MiR-451a and miR-423-3p were significantly correlated with30445461
hsa-mir-451aBMI and HbA1cThe post-training levels of miR-423-3p, miR-451a and miR-766-3p were significantly up-regulated, irrespective of exercise type (P<0.0026; 0.05/19), and targeted upstream pathways relevant to fatty acids biosynthesis and metabolic regulation. MiR-451a and miR-423-3p were significantly correlated with30445461
hsa-mir-766-3pBMI and HbA1cThe post-training levels of miR-423-3p, miR-451a and miR-766-3p were significantly up-regulated, irrespective of exercise type (P<0.0026; 0.05/19), and targeted upstream pathways relevant to fatty acids biosynthesis and metabolic regulation. MiR-451a and miR-423-3p were significantly correlated with30445461
hsa-mir-31IL-6,ICAM-1,Satb21:Serum miR-31 may be a biomarker for DN in T2D patients. The regulation of this miRNA seems to be related to the recruitment of leukocytes to vascular walls induced by pro-inflammatory and adhesion molecules(30355913).2:up-regulation of miR-31 may underlie endothelial dysfunction in diabetes by ta
hsa-mir-20a Pknox11:The ectopic expression of miR-17 or miR-20a could markedly suppress Pknox1 expression in hepatocytes. MiR-17 or miR-20a overexpression also resulted in significantly enhanced insulin sensitivity and reduced hepatocyte steatosis in HepG2 and L02 cells, which were determined by altered phosphorylat
hsa-mir-4463 PNUTSmiR-4463 was elevated in the vascular tissues of patients with T2DM and ASO. Down regulation of miR-4463 attenuates cell apoptosis by directly enhancing PNUTS expression to promote PTEN nuclear localization, subsequently activating AKT signaling pathway in HUVECs under HG and/ or hypoxic conditions.30244253
hsa-mir-212 NA1: On the contrary, the less abundant miRNAs such as miR-212/miR-132, miR-335, miR-130a/b and miR-152 are deregulated in T2D islets, wherein the latter three miRNAs were shown to play key roles in regulating ?-cell metabolism(30230181). 2:dysregulated miRNA expression exacerbates ?-cell dysfunction,
hsa-mir-132 NA 1:On the contrary, the less abundant miRNAs such as miR-212/miR-132, miR-335, miR-130a/b and miR-152 are deregulated in T2D islets, wherein the latter three miRNAs were shown to play key roles in regulating ?-cell metabolism(30230181). 2:dysregulated miRNA expression exacerbates ?-cell dysfunction,
mir-335 NA1: On the contrary, the less abundant miRNAs such as miR-212/miR-132, miR-335, miR-130a/b and miR-152 are deregulated in T2D islets, wherein the latter three miRNAs were shown to play key roles in regulating ?-cell metabolism(30230181). 2:dysregulated miRNA expression exacerbates ?-cell dysfunction,30230181, 2
hsa-mir-28-3p HbA1c1:Patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease (HR= 11.27; 95% CI= 2.61-48.65)(30195754).2:Three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabe
hsa-let-7i-3p, MACA urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. ROC curve analysis confirmed this ability to identify MIC in normo-albuminuria T2DM (T2DM-NA) patients and to differentiate b30165157
hsa-miR-24-3p, MACA urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. ROC curve analysis confirmed this ability to identify MIC in normo-albuminuria T2DM (T2DM-NA) patients and to differentiate b30165157
hsa-miR-27b-3p, MACA urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. ROC curve analysis confirmed this ability to identify MIC in normo-albuminuria T2DM (T2DM-NA) patients and to differentiate b30165157
hsa-miR-15b-5p MACA urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC. ROC curve analysis confirmed this ability to identify MIC in normo-albuminuria T2DM (T2DM-NA) patients and to differentiate b30165157
hsa-mir-125a NA Up regulation of miR-125a in WAT of type 2 Diabetes mellitus have been observed.30150203
hsa-miR-126-3p NAThree miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes.30093963
hsa-miR-486-5p NAThree miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes.30093963
hsa-miR-193b-3p NALevels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls.30083267
hsa-miR-26b-5p NALevels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls.30083267
hsa-miR-374a-5p NALevels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls.30083267
hsa-miR-409-3p NALevels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls.30083267
hsa-miR-95-3p NALevels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls.30083267
hsa-miR-498 CircANKRD36CircANKRD36 may be involved in T2DM and inflammation?associated pathways via interaction with miRNAs, including hsa?miR?3614?3p, hsa?miR?498, and hsa?miR?501?5p. The expression of circANKRD36 was up-regulated in peripheral blood leucocytes and was correlated with chronic inflammation in T2DM30066828
hsa-miR-501-5p CircANKRD36CircANKRD36 may be involved in T2DM and inflammation?associated pathways via interaction with miRNAs, including hsa?miR?3614?3p, hsa?miR?498, and hsa?miR?501?5p. The expression of circANKRD36 was up-regulated in peripheral blood leucocytes and was correlated with chronic inflammation in T2DM30066828
hsa-miR-20b NAPlasma miR-17, miR-20a, miR-20b, and miR-122 were up-regulated in T2DM patients with NAFLD complicated compared in those without NAFLD30030064
hsa-miR-202 CACNA1E Identification of the subpaths of each subtype indicated that the subpath related to subtype 1 was miRNA (miR)?202/calcium voltage?gated channel subunit ?1 (CACNA1E)/type II diabetes mellitus."29981420
miR-676 NA1: Our approach revealed that expression of both the gene encoding ectodysplasin A (Eda), the causal gene in X-linked hypohidrotic ectodermal dysplasia (XLHED), and its intronic miRNA, miR-676, was increased in the livers of obese mice(29770126).2:reducing miR-676 expression in db/db mice increases
hsa-miR-410 LPLevaluated rs13702 (C/T) polymorphism located in miRNA-410 binding site of LPL gene in subset of Iranian T2DM patients and their normal counterparts.29930919
hsa-let-7b NA1:let-7b, miR-142, miR-144, and miR-29a in plasma may be important markers of neuroendocrine stress response and may play a role in the pathogenesis of T2DM and IR(29643835). 2: regression retained let-7b, miR-144-5p, miR-34a, and miR-532-5p in a model predictive of insulin resistance (R2 ?=?0.57, P
hsa-miR-142 NAlet-7b, miR-142, miR-144, and miR-29a in plasma may be important markers of neuroendocrine stress response and may play a role in the pathogenesis of T2DM and IR. 29643835
hsa-miR-223 NA 1:miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD(29615970).2:16 stress-related miRNAs were significantly dysregul
hsa-miR-197 NA miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD.29615970
hsa-miR-191 NA 1:miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD(29615970).2:miR-191 is involved in CSE-induced hepatic insulin r
hsa-miR-140 NA miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD.29615970
hsa-miR-98 NA miRNAs associated with platelet function and reactivity (miR-223, miR-126, miR-197, miR-191, miR-21, miR-150, miR-155, miR-140, miR-96, miR-98) that should be evaluated as novel biomarkers to improve diagnostics and treatment of CVD.29615970
miR-29a-3p Mir29b-1/aIntraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwise exhibited impaired EDVD Intraluminal delivery of anti-miR-29b-3p in arterioles from non-DM human subjects or rats or targeted mutation of Mir29b-1/a 29374012
miR-29b-3p Mir29b-1/aIntraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwise exhibited impaired EDVD Intraluminal delivery of anti-miR-29b-3p in arterioles from non-DM human subjects or rats or targeted mutation of Mir29b-1/a 29374012
hsa-miR-148b NA16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.29341487
hsa-miR-19a NA16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.29341487
hsa-miR-26b NA16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.29341487
hsa-miR-27b NA16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.29341487
miR-203a-3p GRP78miR?203a?3p may have a functional role in endoplasmic reticulum stress (ERS) signaling in the liver of T2DM GK rats. In addition, APS attenuated IR in T2DM, likely through upregulating or maintaining the miR?203a?3p expression levels, decreasing GRP78 mRNA and protein expression levels and regulatin29257218
miR-327 FGF10 miR-327 as one of the most downregulated miRNAs targeting growth factors in the stromal-vascular fraction (SVF) under conditions that promote white adipose tissue (WAT) browning in mice. Gain- and loss-of-function experiments reveal that miR-327 targets FGF10 to prevent beige adipocyte differentia29233981
miR-454-3p NAmiR-454-3p was overexpressed in both LBW and macrosomia (19.7-fold, p < 0.001 and 10.8-fold, p < 0.001, respectively), as compared to NBW.29182561
hsa-miR-362-3p NA MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD.29038788
hsa-miR-877-3p NA MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD.29038788
hsa-miR-15a-5p NA MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD.29038788
hsa-miR-486 NAmiR-486 was implicated in accelerating preadipocyte proliferation and myotube glucose intolerance, miR-146b and miR-15b were engaged in the suppression of high concentration glucose-induced pancreatic insulin secretion, and they all contributed to the pathological processes of obesity and T2D.circul28966078
hsa-miR-146b NAmiR-486 was implicated in accelerating preadipocyte proliferation and myotube glucose intolerance, miR-146b and miR-15b were engaged in the suppression of high concentration glucose-induced pancreatic insulin secretion, and they all contributed to the pathological processes of obesity and T2D.circul28966078
hsa-miR-7 NA1:reduction of circulating miR-7 and miR-192, accompanied by elevation of miR-152, reflects a beneficial metabolic response to vitamin D treatment in people with prediabetes. These miRNAs may be useful biomarkers in diabetes prevention trials and other studies of vitamin D(28945992).2:Increased ser
hsa-miR-342 NAthe top differentially expressed biomarkers in people with IGT/ reduced ?-cell glucose sensitivity were adiponectin, alpha1-antitrypsin (known to regulate adiponectin levels), endocan, miR-181a, miR-342, and miR-323.28846711
hsa-miR-323 NAthe top differentially expressed biomarkers in people with IGT/ reduced ?-cell glucose sensitivity were adiponectin, alpha1-antitrypsin (known to regulate adiponectin levels), endocan, miR-181a, miR-342, and miR-323.28846711
hsa-miR-144-5p NAregression retained let-7b, miR-144-5p, miR-34a, and miR-532-5p in a model predictive of insulin resistance (R2 ?=?0.57, P?=?7.5??10-8 ). Both miR-378a and miR-122 were perturbed in metabolically relevant tissues in a murine model of obesity. This study expands on the role of extracellular miRNAs 28834285
hsa-miR-532-5p NAregression retained let-7b, miR-144-5p, miR-34a, and miR-532-5p in a model predictive of insulin resistance (R2 ?=?0.57, P?=?7.5??10-8 ). Both miR-378a and miR-122 were perturbed in metabolically relevant tissues in a murine model of obesity. This study expands on the role of extracellular miRNAs 28834285
miRNA-378 NAMiRNA-378 was found to be significantly increased in db/db mice. PNPase as a contributor to mitochondrial miRNA import through the transport of miRNA-378, which may regulate bioenergetics during type 2 diabetes mellitus.28709769
hsa-miR-18a NA MiR-18a and miR-34c in PBMCs may be important marker of stress reaction and may play a role in vulnerability to T2DM as well as IR. 28661068
hsa-miR-34c NA MiR-18a and miR-34c in PBMCs may be important marker of stress reaction and may play a role in vulnerability to T2DM as well as IR. 28661068
miR-214 MEG3MEG3 promoted hepatic insulin resistance by serving as a ceRNA of miR?214 to facilitate ATF4 expression. These data provide insight into the molecular mechanism of MEG3 involvement in the development of type 2 diabetes mellitus.30431065
miR-33-5p NA Decreased miR-33-5p levels were found in the urine of db/db mice and type 2 DM patients, and miR-33-55p levels negatively correlated with albuminuria. Angpt2 leads to MC apoptosis via the miR-33-5p-SOCS5 loop in DN. miR-33-5p is predictive of kidney injury in DN. These findings may provide future a30414568
miR-128-3p ISL1 miR-128-3p aggravates cardiovascular calcification and IR in T2DM rats by downregulating ISL1 through the activation of the Wnt pathway. Thus, miR-128-3p may serve as a potential target for the treatment of T2DM.30341898
miR-6835-3p NAtargeting AdipoR1 with miR?6835?3p inhibitors may be a potential strategy for promoting glucose?stimulated insulin secretion, and thereby, may be an effective treatment for type 2?DM.29916530
hsa-miR-377 NA blood?based miR?377 and miR?192 may serve as potential biomarkers for early detection of DN.29845236
miR-219 NAthe upregulation of miR-219 decreases LTP inhibition and hippocampal neuronal cell apoptosis in T2DM mice by downregulating the NMDAR signaling pathway, therefore suggesting that MiR-219 might be a future therapeutic strategy for T2DM.29804319
miR-301b NAtranslational regulation by miR-301b mediates upregulated expression of cardiac AMPD3 protein in OLETF, which potentially reduces the adenine nucleotide pool at the time of increased work load. The miR-301b-AMPD3 axis may be a novel therapeutic target for intervening enegy metabolism in diabetic hea29733818
miR-216b NA MicroRNA-216b was overexposed in diabetic MMECs and its downregulation may actively enhance angiogenesis in diabetic angiopathy through inverse regulation on FZD5.29477872
miR-29 NA the miR-29 family negatively regulates glucose metabolism by inhibiting SPARC expression.29462611
miR-330-5p NA miR-330-5p served as a regulator of the M2 polarization and miR-330-5p/Tim-3 axis potentially down-regulated insulin resistance in diabetes, probably through enhancing the M2 polarization of macrophage.29433065
hsa-miR-448 NAmiR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.29428938
hsa-miR-296-5pbak/bax, bcl-2 VSMCs, from human atherosclerotic arteries of individuals with T2D, express low bak/bax and high bcl-2 and miR-296-5p levels.29386225
hsa-miR-125b NA alteration of miR-34a and miR-125b exists in patients with T2DM, which may be involved in the pathogenesis of T2DM, and could be a potential novel biomarker of T2DM.29285097
miR-148 NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-222 NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-99 NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
let-7d NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-18a NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-18b NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-23a NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-28 NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
miR-30d NA impaired glucose tolerance associated with a global increase of plasma circulating microRNAs. While miR-148 and miR-222 were specifically modulated in diabetic subjects and correlated with parameters of glucose tolerance, the most accentuated microRNA dysregulation was found in NP IGT subjects, with29200427
hsa-miR-146a NA 1:miR-146a circulating levels were significantly elevated in controls compared with T2D patients. In addition, we identified that rs2910164-C allele is associated with reduced expression levels of the miR-146a but not its mRNAs targets and cytokine levels in diabetic patients( 29058209).2:miR-146a
miR-200c NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-322 NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-331 NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-546 NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-301a NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-409 NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-542 NATo unravel the possible mechanism(s) involved in this process, microRNA (miR) expression profile, which was assessed using TLDA technique and thereafter confirmed by individual qRT-PCR, revealed differential expression 10 miRs, five at day 3 and 5 at day 6 post Pi treatment versus control untreated 28776684
miR-193-5p IGF2 MiR-193-5p is an active angiogenic factor in diabetic cardiomyopathy, possibly through inverse regulation on its downstream IGF2 gene.28735866
miR-27b NA miR-27b prevents EPC apoptosis in Type 2 diabetic mice, at least in part, by suppressing p53 and the Bax/Bcl-2 ratio. These findings may provide a mechanistic basis for rescuing BMPC dysfunction in diabetes for successful autologous cell therapy.28698281
miR-181b NA NEAT1 was potentially communicated with mTOR signalling target protein mLST8 via the association with miR-181b.28643459