| TPCN2 |
| LOCUS ID | 219931 |
| GENE_SYMBOL | TPCN2 |
| GENE NAME | two pore segment channel 2 |
| SYNONYMNS | TPC2 SHEP10 |
| CHROMOSOME | 11 |
| HOMOLOGENE ID | 16375 |
| GENE SUMMARY |
|---|
| This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009] |