GCG
LOCUS ID2641
GENE_SYMBOLGCG
GENE NAMEglucagon
SYNONYMNSGLP1, GLP2, GRPP
CHROMOSOME2
HOMOLOGENE ID181
DiseaseType 2 diabetes
PMIDs23185367
GENE SUMMARY
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]

OBSERVATIONS
Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment.