AHSG
LOCUS ID197
GENE_SYMBOLAHSG
GENE NAMEalpha-2-HS-glycoprotein
SYNONYMNSAHS, A2HS, HSGA, FETUA
CHROMOSOME3
HOMOLOGENE ID1225
microRNAsNANA
GENE SUMMARY
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mR. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Fetuin-A is demonstrated as a risk factor for both microalbuminuria and reduction of GFR in diabetic nephropathy with the odds ratio of 4.721 (1.881-11.844) and 3. 739 (1.785-7.841), respectively.Collectively, the glycan profiling analysis is useful method to identify the urine biomarkers and fetuin-A is a candidate to predict the progression of diabetic nephropathy.24143207
Cardiovascular1. Fetuin-A has a diagnostic potential as a biomarker for liver dysfunction, cardiovascular diseases and disorders associated with metabolic syndrome.25916279
Retinopathy1. The occurrence and severity of DR is correlated with serum and vitreous fetuin-A concentrations.26110737