| ALOX5AP |
| LOCUS ID | 241 | |||||||||||||
| GENE_SYMBOL | ALOX5AP | |||||||||||||
| GENE NAME | arachidonate 5-lipoxygenase-activating protein | |||||||||||||
| SYNONYMNS | FLAP | |||||||||||||
| CHROMOSOME | 13 | |||||||||||||
| HOMOLOGENE ID | 1231 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. FLAP antagonist administration decreased proteinuria in glomerulonephritic patients. 2. These suggest a role for FLAP other than the activation of 5-LO, possibly in protein handling, and point to FLAP antagonists as anti-proteinuric agents. | 12649539 |
| Atherosclerosis | 1. Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes. | 20592751 |