ALOX5AP
LOCUS ID241
GENE_SYMBOLALOX5AP
GENE NAMEarachidonate 5-lipoxygenase-activating protein
SYNONYMNSFLAP
CHROMOSOME13
HOMOLOGENE ID1231
microRNAsNANA
GENE SUMMARY
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. FLAP antagonist administration decreased proteinuria in glomerulonephritic patients. 2. These suggest a role for FLAP other than the activation of 5-LO, possibly in protein handling, and point to FLAP antagonists as anti-proteinuric agents.12649539
Atherosclerosis1. Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes.20592751