APLN
LOCUS ID8862
GENE_SYMBOLAPLN
GENE NAMEapelin
SYNONYMNSAPEL,XNPEP2
CHROMOSOMEX
HOMOLOGENE ID8498
microRNAsNANA
GENE SUMMARY
This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Apelin level is found significantly higher in diabetic neuropathy group than the diabetic milletus group.Elevated apelin levels may indicate the metabolic state causing diabetic complications.27010147