AQP4
LOCUS ID361
GENE_SYMBOLAQP4
GENE NAMEaquaporin 4
SYNONYMNSMIWC, WCH4
CHROMOSOME18
HOMOLOGENE ID37507
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predomint aquaporin found in brain and has an important role in brain water homeostasis. Altertively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translatiol readthrough in this gene and expression of an additional C-termilly extended isoform via the use of an altertive in-frame translation termition codon. [provided by RefSeq, Dec 2015]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. streptozotocin injection induced diabetes resulted in compensatory increases of AQP4 expression, and downregulation of AQP4 exacerbated diabetic retinopathy through aggravating inflammatory response, at last in part. Therefore, regulation of retinal function by AQP4 may attenuate diabetic retinopathy, offering a promising therapeutic strategy for diabetic retinopathy.22449442