CCL5
LOCUS ID6352
GENE_SYMBOLCCL5
GENE NAMEC-C motif chemokine ligand 5
SYNONYMNSSISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta
CHROMOSOME17
HOMOLOGENE ID2244
microRNAsNANA
GENE SUMMARY
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-termil cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the tural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Altertive splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy. Chemokine (C-C motif) ligand 5 (CCL5) and chemokine (C-C motif) receptor 5 are implicated in the pathogenesis of diabetic nephropathy (DN).20203694
Tuberculosis1. Lung leukocyte aggregates at the initial sites of M. tuberculosis infection developed later in diabetic than in nondiabetic mice, possibly related to reduced levels of leukocyte chemoattractant factors including CCL2 and CCL5 at early time points postinfection20421645