CCR5
LOCUS ID1234
GENE_SYMBOLCCR5
GENE NAMEchemokine (C-C motif) receptor 5 (gene/pseudogene)
SYNONYMNSCKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22,
CHROMOSOME3
HOMOLOGENE ID37325
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the beta chemokine receptor family which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages and is known to be an important co-receptor for macrophage-tropic virus including HIV to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2) macrophage inflammatory protein 1 alpha (MIP-1 alpha) macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gen

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. neferine can decrease the expression of CCL5 and CCR5 in the superior cervical ganglion (SCG) and reduce the SCG neuronal signaling mediated by CCL5 and CCR5 in regulating diabetic cardiovascular autonomic complications23063706
Atherosclerosis1. Overexpression of the CCR5 receptor should be considered as a factor that promotes the development of atherosclerosis in diabetic patients16708639