CD14
LOCUS ID929
GENE_SYMBOLCD14
GENE NAMECD14 molecule
SYNONYMNS
CHROMOSOME5
HOMOLOGENE ID493
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. Reduced MARCO and CD14 expression contributes to defective sentinel function of alveolar macrophages, promoting tuberculosis susceptibility in diabetic hosts at a critical early step in the immune response to aerosol infection27630197