CDK7
LOCUS ID1022
GENE_SYMBOLCDK7
GENE NAMEcyclin-dependent kinase 7
SYNONYMNSCAK1, HCAK, MO15, STK1, CDKN7, p39MO15
CHROMOSOME5
HOMOLOGENE ID1363
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and D repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In the kidneys of the GK rat, a model of type II diabetes, CDK7 showed a steady age-related increase in mRNA , increasing to >sixfold in 40 week GK rats compared to normoglycemic age-matched Wistar rat kidneys, this increase correlates with progressive hyperglycemia.17416350