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CEBPB |
LOCUS ID | 1051 | ||||||||||
GENE_SYMBOL | CEBPB | ||||||||||
GENE NAME | CCAAT enhancer bindi | ||||||||||
SYNONYMNS | TCF5 IL6DBP NF-IL6 C/EBP-beta | ||||||||||
CHROMOSOME | 20 | ||||||||||
HOMOLOGENE ID | 3807 |
microRNAs | NA | NA |
GENE SUMMARY |
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This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functi |
OBSERVATIONS |
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Complication | Evidence | PMID |
Insulin resistance and inflammation | 1. Global C/EBP? (CEBPB) deletion prevented HFD-induced inflammation and surprisingly increased mitochondrial gene expression in white adipose tissue along with brown adipose tissue markers PRDM16, CIDEa, and UCP1, consistent with a resistance to HFD-induced obesity. | 22902781 |