CNR2
LOCUS ID1269
GENE_SYMBOLCNR2
GENE NAMEcanbinoid receptor 2 (macrophage)
SYNONYMNSCB2, CX5, CB-2
CHROMOSOME1
HOMOLOGENE ID1389
microRNAsNANA
GENE SUMMARY
The canbinoid delta-9-tetrahydrocanbinol is the principal psychoactive ingredient of marijua. The proteins encoded by this gene and the canbinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for canbinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the canbinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijua. The canbinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. CB2 was downregulated in kidney biopsies from patients with advanced DN, and renal levels of the CB2 ligand 2-arachidonoylglycerol were reduced in diabetic mice, suggesting impaired CB2 regulation 2. The CB2 receptor is expressed by podocytes, and in experimental diabetes, CB2 activation ameliorates both albuminuria and podocyte protein loss, suggesting a protective effect of signaling through CB2 in DN21810593
Neuropathy1. When initiated in an established DPN NeP state, both CB1 and CB2 agonists demonstrated an antinociceptive effect until their discontinuation.20236533