CNTF
LOCUS ID1270
GENE_SYMBOLCNTF
GENE NAMEciliary neurotrophic factor
SYNONYMNSHCNTF
CHROMOSOME11
HOMOLOGENE ID8288
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Olmesartan medoxomil significantly enhanced the CNTF expression. These showed that angiotensin II type1 receptor blocker treatment is effective on nerve regeneration delay in diabetic animals and may provide an effective therapy for clinical diabetic neuropathy.19786922