CTGF
LOCUS ID1490
GENE_SYMBOLCTGF
GENE NAMEconnective tissue growth factor
SYNONYMNSCCN2, NOV2, HCS24, IGFBP8
CHROMOSOME6
HOMOLOGENE ID1431
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Connective Tissue Growth Factor (CTGF/CCN2) is an important mediator of kidney fibrosis.23199377
Retinopathy1. In mice infused with exogenous Advanced glycation end product (AGE), Cyr61 expression increased fourfold and Ctgf expression increased two fold in the retina.17333105
Neuropathy1. In this study, CTGF, HO-1 and NT-3 were highly correlated with type 2 diabetic peripheral neuropathy. The conduction velocity of nerve increased with the increase of CTGF, HO-1 and NT-3. Immune cytokine TGF-?1 combined with cattle encephalon glycoside and ignotin injection could improve the contents of CTGF, HO-1 and NT-3, and be better to treat the peripheral neuropathy of type 2 diabetes. 29259937
Cardiovascular1. CONCLUSIONS: Our study indicates that high levels of CTGF/CCN2 predict future MI and cardiovascular death in patients with type 2 diabetes. \302\251 2018 by the American Diabetes Association.29382658