CTGF
LOCUS ID1490
GENE_SYMBOLCTGF
GENE NAMEconnective tissue growth factor
SYNONYMNSCCN2, NOV2, HCS24, IGFBP8
CHROMOSOME6
HOMOLOGENE ID1431
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Connective Tissue Growth Factor (CTGF/CCN2) is an important mediator of kidney fibrosis.23199377
Retinopathy1. In mice infused with exogenous Advanced glycation end product (AGE), Cyr61 expression increased fourfold and Ctgf expression increased two fold in the retina.17333105