CX3CR1
LOCUS ID1524
GENE_SYMBOLCX3CR1
GENE NAMEchemokine (C-X3-C motif) receptor 1
SYNONYMNSV28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1
CHROMOSOME3
HOMOLOGENE ID20350
microRNAsNANA
GENE SUMMARY
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Fractalkine and CX3CR1 upregulation were demonstrated in an early stage of diabetic kidney. These upregulation, as well as Urinary albumin excretion, were suppressed by treatments with temocapril and aminoguanidine for 8 weeks. These findings suggest that fractalkine expression and CX3CR1-positive cell infiltration in diabetic kidneys might play an important role for progression of diabetic nephropathy.15153757