CXCL12
LOCUS ID6387
GENE_SYMBOLCXCL12
GENE NAMEchemokine (C-X-C motif) ligand 12
SYNONYMNSIRH, PBSF, SDF1, TLSF, TPAR1, SCYB12
CHROMOSOME10
HOMOLOGENE ID128606
microRNAsNANA
GENE SUMMARY
This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Immunostaining localised renal CXCL12 production to glomerular podocytes in db/db mice with early or advanced diabetic nephropathy. We conclude that podocytes produce CXCL12, which contributes to proteinuria and glomerulosclerosis in our mouse model of type 2 diabetes. This novel pathomechanism provides the first evidence that CXCL12 could be a therapeutic target in (diabetic) glomerulosclerosis.19707743