| CXCL12 |
| LOCUS ID | 6387 | |||||||||||||
| GENE_SYMBOL | CXCL12 | |||||||||||||
| GENE NAME | chemokine (C-X-C mot | |||||||||||||
| SYNONYMNS | IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12 | |||||||||||||
| CHROMOSOME | 10 | |||||||||||||
| HOMOLOGENE ID | 128606 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple trans |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Immunostaining localised renal CXCL12 production to glomerular podocytes in db/db mice with early or advanced diabetic nephropathy. We conclude that podocytes produce CXCL12, which contributes to proteinuria and glomerulosclerosis in our mouse model of type 2 diabetes. This novel pathomechanism provides the first evidence that CXCL12 could be a therapeutic target in (diabetic) glomerulosclerosis. | 19707743 |
| Insulin resistance and inflammation | 1. Diet-induced obese mice demonstrated a robust increase of CXCL12 expression in white adipose tissue (WAT). | 24744121 |