CXCL5
LOCUS ID6374
GENE_SYMBOLCXCL5
GENE NAMEchemokine (C-X-C motif) ligand 5
SYNONYMNSSCYB5, E-78
CHROMOSOME4
HOMOLOGENE ID88672
microRNAsNANA
GENE SUMMARY
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Increased urinary levels of CXCL5, CXCL8 and CXCL9 in patients with Type 2 diabetic nephropathy. 2. These suggest that these three CXC chemokines may be involved in the progression of human Type 2 diabetic nephropathy and that CXCL5 may be of use for telling diabetic nephropathy from primary renal diseases.18413205
Atherosclerosis1. Serum CXCL5 is an important determinant of carotid artery intima-media thickness (IMT) in patients with type 2 diabetes.21609350