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EGF |
LOCUS ID | 1950 | |||||||||||||
GENE_SYMBOL | EGF | |||||||||||||
GENE NAME | epidermal growth factor | |||||||||||||
SYNONYMNS | URG, HOMG4 | |||||||||||||
CHROMOSOME | 4 | |||||||||||||
HOMOLOGENE ID | 1483 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. In serum, MCP-1, FGF-2, VEGF, and EGF levels were elevated above controls at all stages of DN. | 26116588 |
Retinopathy | 1. Serum ET, Follistatin and EGF were significantly higher in DR patients as compared to those without DR and should be considered to be significant biomarkers of retinal complications in diabetes mellitus. | 30158034 |