EGF
LOCUS ID1950
GENE_SYMBOLEGF
GENE NAMEepidermal growth factor
SYNONYMNSURG, HOMG4
CHROMOSOME4
HOMOLOGENE ID1483
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Altertive splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In serum, MCP-1, FGF-2, VEGF, and EGF levels were elevated above controls at all stages of DN.26116588