EIF2AK3
LOCUS ID9451
GENE_SYMBOLEIF2AK3
GENE NAMEeukaryotic translation initiation factor 2-alpha kinase 3
SYNONYMNSPEK, WRS, PERK
CHROMOSOME2
HOMOLOGENE ID3557
microRNAsmiR-34a-5p26969487
GENE SUMMARY
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its ictivation, and thus to a rapid reduction of translatiol initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. With a single injection of streptozotocin 65 mg/kg, ip in rats, early diabetic nephropathy was produced and revealed as an increased microalbuminuria, elevated creatinine and urea in serum, associated with upregulation of mRNA and protein of DPH oxidase p22phox, p47phox, and p67phox and ET(A), upregulated PKR-like eukaryotic initiation factor 2 alpha kinase (PERK), and downregulated Cx43 in the renal tissue.21267711