F2R
LOCUS ID2149
GENE_SYMBOLF2R
GENE NAMEcoagulation factor II (thrombin) receptor
SYNONYMNSTR, HTR, CF2R, PAR1, PAR-1
CHROMOSOME5
HOMOLOGENE ID1510
microRNAsNANA
GENE SUMMARY
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The up-regulation of PAR-1 in glomeruli in diabetic mice may play a role in the progression of glomerulosclerosis and abnormal Urinary albumin excretion in diabetic nephropathy.19401193